diff --git a/dockers/docker-platform-monitor/Dockerfile.j2 b/dockers/docker-platform-monitor/Dockerfile.j2
index 21536f43c0..4f5e941dd9 100755
--- a/dockers/docker-platform-monitor/Dockerfile.j2
+++ b/dockers/docker-platform-monitor/Dockerfile.j2
@@ -20,7 +20,6 @@ RUN apt-get update &&   \
         librrd8         \
         librrd-dev      \
         rrdtool         \
-        python-smbus    \
         python3-smbus   \
         dmidecode       \
         i2c-tools       \
@@ -28,29 +27,15 @@ RUN apt-get update &&   \
         python3-jsonschema \
         libpci3
 
-# TODO: Remove these lines once we no longer need Python 2
-RUN apt-get install -f -y python-dev python-pip
-RUN pip2 install --upgrade 'pip<21'
-RUN apt-get purge -y python-pip
-RUN pip2 install 'setuptools==40.8.0'
-
 # On Arista devices, the sonic_platform wheel is not installed in the container.
 # Instead, the installation directory is mounted from the host OS. However, this method
 # doesn't ensure all dependencies are installed in the container. So here we
 # install any dependencies required by the Arista sonic_platform package.
 # TODO: eliminate the need to install these explicitly.
-# NOTE: Only install enum34 for Python 2, as our version of Python 3 is 3.7, which
-# contains 'enum' as part of the standard library. Installing enum34 there will
-# cause conflicts.
-RUN pip2 install enum34 \
-        grpcio==1.39.0 \
-        grpcio-tools==1.39.0
-
 RUN pip3 install grpcio==1.39.0 \
         grpcio-tools==1.39.0
 
 # Barefoot platform vendors' sonic_platform packages import the Python 'thrift' library
-RUN pip2 install thrift==0.13.0
 RUN pip3 install thrift==0.13.0
 
 {% if docker_platform_monitor_debs.strip() -%}
@@ -78,9 +63,6 @@ RUN pip3 install thrift==0.13.0
 {% endif %}
 
 
-# TODO: Remove this line once we no longer need Python 2
-RUN apt-get purge -y python-dev
-
 # Clean up
 RUN apt-get purge -y           \
         build-essential        \
diff --git a/rules/docker-platform-monitor.mk b/rules/docker-platform-monitor.mk
index 84bffd3c61..e4b300834a 100644
--- a/rules/docker-platform-monitor.mk
+++ b/rules/docker-platform-monitor.mk
@@ -6,23 +6,13 @@ DOCKER_PLATFORM_MONITOR_DBG = $(DOCKER_PLATFORM_MONITOR_STEM)-$(DBG_IMAGE_MARK).
 
 $(DOCKER_PLATFORM_MONITOR)_PATH = $(DOCKERS_PATH)/$(DOCKER_PLATFORM_MONITOR_STEM)
 
-$(DOCKER_PLATFORM_MONITOR)_DEPENDS += $(LIBSENSORS) $(LM_SENSORS) $(FANCONTROL) $(SENSORD) $(LIBSWSSCOMMON) $(PYTHON_SWSSCOMMON) $(PYTHON3_SWSSCOMMON) $(SMARTMONTOOLS) $(ETHTOOL)
+$(DOCKER_PLATFORM_MONITOR)_DEPENDS += $(LIBSENSORS) $(LM_SENSORS) $(FANCONTROL) $(SENSORD) $(LIBSWSSCOMMON) $(PYTHON3_SWSSCOMMON) $(SMARTMONTOOLS) $(ETHTOOL)
 
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PLATFORM_COMMON_PY2)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PLATFORM_COMMON_PY3)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SWSSSDK_PY2)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SWSSSDK_PY3)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PY_COMMON_PY2)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PY_COMMON_PY3)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_CONFIG_ENGINE_PY2)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PLATFORM_API_PY2)
+$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_CONFIG_ENGINE_PY3)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PLATFORM_API_PY3)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_LEDD_PY2)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PCIED_PY2)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PSUD_PY2)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_SYSEEPROMD_PY2)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_THERMALCTLD_PY2)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_XCVRD_PY2)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_LEDD_PY3)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PCIED_PY3)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_PSUD_PY3)
@@ -32,7 +22,6 @@ $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_XCVRD_PY3)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(SONIC_CHASSISD_PY3)
 
 ifeq ($(PDDF_SUPPORT),y)
-$(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(PDDF_PLATFORM_API_BASE_PY2)
 $(DOCKER_PLATFORM_MONITOR)_PYTHON_WHEELS += $(PDDF_PLATFORM_API_BASE_PY3)
 endif